Product name: 2-Methoxyestradiol
CAS: 362-07-2
Molecular formula: C19H26O3
Molecular weight: 302.41
Description: 2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.
It also acts as a vasodilator.
2ME2 is derived from estrogen, although it binds poorly to known estrogen receptors.
It induces apoptosis in some cancer cell lines.
It has undergone Phase 1 clinical trials against breast cancer.