Pemetrexed disodium
Update£º2014-01-31 16:31:47 Click£º
- Product Brand AUS
- Product type
Description
Product name: Pemetrexed disodiumSynonyms: Premetre disodium
Assay£º99%
Molecular formula: C20H33N5Na2O13
Molecular weight: 597.4813
Appearance: White to light yellow or greenish of freeze-drying solid
CAS: 150399-23-8
Indication: This product is suitable for combination therapy with cisplatin inoperable malignant pleural mesothelioma.
Pharmacology: Pemetrexed carrier and by carrying folate folate binding protein on the cell membrane transport system into the cell. Once pemetrexed into the cell, it more acid in the leaves under the action of glutamate synthase glutamate into many forms. More glutamate into the cell to survive in thymidylate synthase and Gly amide nucleotide carbamoyl transferase inhibitors. More glutamate in tumor cells of presentation time - concentration-dependent process, but the concentration is very low in normal tissues. More glutamic acid metabolites in tumor cells of the half-life extension, which will extend the drug in tumor cells, the role of time.
Preclinical studies have shown that pemetrexed can inhibit mesothelioma cell lines in vitro (MSTO? 211H, NCI? H2052) growth. Mesothelioma cell line MSTO? 211H studies have shown that pemetrexed and cisplatin have synergistic effect
More
