Methotrexate
Update£º2014-01-31 16:10:21 Click£º
- Product Brand AUS
- Product type
Description
Product name: MethotrexateSynonyms: (+)-Amethopterin; (+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid
Molecular formula: C20H22N8O5
Molecular weight: 454.44
Appearance: Orange yellow crystal powder
CAS: 59-05-2
Assay£º99%
Indication: Used in the treatment of acute lymphocytic leukemia, lymphoma, malignant hydatidiform mole, velvet carcinoma, squamous cell carcinoma, lung, breast and cervical, caruncle osteogenesis.
Pharmacology: Tetrahydrofolate is synthesized in the body of purine and pyrimidine nucleotides deoxynucleotidyl important coenzyme. The product as a reductase inhibitors, mainly inhibiting dihydrofolate dihydrofolate reductase leaving with physical activity can not be reduced to the tetrahydro folic acid, so that the purine nucleotides and pyrimidine nucleotide biosynthesis a role in the transfer of carbon-based group blocked, resulting in DNA biosynthesis was inhibited. In addition, the product also has effects on the thymus nucleotide synthase inhibition, but inhibition of RNA and protein synthesis was relatively weak. This product is a major role in cell cycle S phase, is cell cycle specific drug, on the G1 / S phase cells have delayed effect on G1 phase cells are less effective.
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