Topotecan HCL
Update£º2014-01-31 16:46:44 Click£º
- Product Brand AUS
- Product type
Description
Product name: Topotecan HCLSynonyms: Topotecan Hydrochloride; Nogitecan hydrochloride; Hycamtin
Assay: 99%
Molecular formula: C23H23N3O5.HCl;C23H24ClN3O5
Molecular weight: 457.91
Appearance: Buff needle crystal or crystalline powder
CAS: 119413-54-6
Indication: For ovarian cancer, breast cancer, rectal cancer, colon cancer, acute and chronic diseases such as white blood cells
Pharmacology: Topology isomerase ¢ñ can induce DNA bases reversible fracture, and make DNA spiral chain loose solution .This product is topological isomerase ¢ñ inhibitors. It can be used with topoisomerase ¢ñ-DNA complex integration and prevent these single-unit chain of reconnect.Its cytotoxicity is in DNA synthesis. It and topoisomerase¢ñ and the formation of the ternary complex of DNA and RNA polymerase interaction produces double strand DNA damage, but mammalian cells cannot effectively fix the DNA double-strand break the chain.
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